Drug interactions
Indacaterol inhaled + Levofloxacin
Severity: Moderate
Indacaterol inhaled and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol can cause small QTc increases and hypokalemia, and levofloxacin prolongs the QT interval. Combined use may modestly increase the risk of ventricular arrhythmias, mostly in patients with cardiac disease or other risk factors.
What this interaction means in plain words
Indacaterol inhaled and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta2-agonist-induced hypokalemia and sympathetic stimulation adding to arrhythmia risk.
What to do
Monitor for palpitations or syncope and check potassium in patients with risk factors. Obtain an ECG if there is underlying QT prolongation or cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Indacaterol inhaled with Levofloxacin?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol can cause small QTc increases and hypokalemia, and levofloxacin prolongs the QT interval. Combined use may modestly increase the risk of ventricular arrhythmias, mostly in patients with cardiac disease or other risk factors.
How serious is the interaction between Indacaterol inhaled and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for palpitations or syncope and check potassium in patients with risk factors. Obtain an ECG if there is underlying QT prolongation or cardiac disease.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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