Drug interactions
Indacaterol inhaled + Maprotiline
Severity: Moderate
Indacaterol inhaled and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline can prolong the QT interval and indacaterol, a long-acting beta2 agonist, may affect cardiac repolarization and heart rate. Together they may raise the risk of ventricular arrhythmias, mostly in patients with other risk factors.
What this interaction means in plain words
Indacaterol inhaled and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and beta2-agonist related hypokalemia and tachycardia.
What to do
Monitor ECG and serum potassium in patients with cardiac disease or other QT-prolonging risks. Consider alternatives if QTc lengthens significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Indacaterol inhaled with Maprotiline?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline can prolong the QT interval and indacaterol, a long-acting beta2 agonist, may affect cardiac repolarization and heart rate. Together they may raise the risk of ventricular arrhythmias, mostly in patients with other risk factors.
How serious is the interaction between Indacaterol inhaled and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium in patients with cardiac disease or other QT-prolonging risks. Consider alternatives if QTc lengthens significantly.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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