Drug interactions
Indacaterol inhaled + Nadolol
Severity: Major
Indacaterol inhaled and Nadolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol, a nonselective beta blocker, antagonizes the bronchodilator effect of indacaterol and may cause severe bronchospasm in patients with asthma or COPD.
What this interaction means in plain words
Indacaterol inhaled and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Competitive antagonism at beta-2 adrenergic receptors in the airways.
What to do
Avoid nonselective beta blockers in patients needing indacaterol; if a beta blocker is essential, use a cardioselective agent with respiratory monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Indacaterol inhaled with Nadolol?
MediHelp rates the interaction as major. Indacaterol inhaled and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nadolol, a nonselective beta blocker, antagonizes the bronchodilator effect of indacaterol and may cause severe bronchospasm in patients with asthma or COPD.
How serious is the interaction between Indacaterol inhaled and Nadolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid nonselective beta blockers in patients needing indacaterol; if a beta blocker is essential, use a cardioselective agent with respiratory monitoring.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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