Drug interactions
Indacaterol inhaled + Quinidine
Severity: Moderate
Indacaterol inhaled and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine prolongs the QT interval, and long-acting beta-agonists like indacaterol can cause tachycardia, hypokalemia and, at high exposure, QTc effects. Together they may raise the risk of ventricular arrhythmias, mainly in patients with other risk factors.
What this interaction means in plain words
Indacaterol inhaled and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive proarrhythmic effects from QT prolongation and beta-agonist-induced hypokalemia and tachycardia.
What to do
Monitor ECG and serum potassium, and do not exceed the recommended indacaterol dose. Consider alternatives in patients with known QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Indacaterol inhaled with Quinidine?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine prolongs the QT interval, and long-acting beta-agonists like indacaterol can cause tachycardia, hypokalemia and, at high exposure, QTc effects. Together they may raise the risk of ventricular arrhythmias, mainly in patients with other risk factors.
How serious is the interaction between Indacaterol inhaled and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium, and do not exceed the recommended indacaterol dose. Consider alternatives in patients with known QT prolongation.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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