Drug interactions
Indacaterol inhaled + Thioridazine
Severity: Major
Indacaterol inhaled and Thioridazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol can prolong the QT interval and cause hypokalemia, and thioridazine strongly prolongs QT. Together they may increase the risk of ventricular arrhythmias.
What this interaction means in plain words
Indacaterol inhaled and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia and tachycardia potentially increasing arrhythmia risk.
What to do
Avoid if possible; if combined, check ECG, potassium and magnesium at baseline and periodically, and consider a non-QT-prolonging antipsychotic.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Indacaterol inhaled with Thioridazine?
MediHelp rates the interaction as major. Indacaterol inhaled and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indacaterol can prolong the QT interval and cause hypokalemia, and thioridazine strongly prolongs QT. Together they may increase the risk of ventricular arrhythmias.
How serious is the interaction between Indacaterol inhaled and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if combined, check ECG, potassium and magnesium at baseline and periodically, and consider a non-QT-prolonging antipsychotic.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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