Drug interactions
Indacaterol inhaled + Tranylcypromine
Severity: Major
Indacaterol inhaled and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol labeling advises extreme caution with MAO inhibitors because they may potentiate the cardiovascular effects of beta-2 agonists. This may cause tachycardia, blood pressure changes and QT prolongation with arrhythmia risk.
What this interaction means in plain words
Indacaterol inhaled and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition may potentiate beta-agonist adrenergic cardiovascular effects, including QTc prolongation.
What to do
Prefer an alternative bronchodilator if possible. If combined, monitor heart rate, blood pressure and ECG, especially after initiation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Indacaterol inhaled with Tranylcypromine?
MediHelp rates the interaction as major. Indacaterol inhaled and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indacaterol labeling advises extreme caution with MAO inhibitors because they may potentiate the cardiovascular effects of beta-2 agonists. This may cause tachycardia, blood pressure changes and QT prolongation with arrhythmia risk.
How serious is the interaction between Indacaterol inhaled and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative bronchodilator if possible. If combined, monitor heart rate, blood pressure and ECG, especially after initiation.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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