Drug interactions
Indacaterol inhaled + Umeclidinium-vilanterol
Severity: Major
Indacaterol inhaled and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol and indacaterol are both long-acting beta2-agonists, so using them together duplicates therapy and increases adrenergic effects. Tachycardia, palpitations, tremor, hypokalemia and arrhythmias become more likely, particularly in patients with cardiovascular disease.
What this interaction means in plain words
Indacaterol inhaled and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive beta2-adrenergic receptor stimulation from two long-acting beta-agonists.
What to do
Avoid concurrent use of two LABA-containing products and choose one regimen. If an overlap has occurred, monitor heart rate, blood pressure, potassium and ECG as indicated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Frequently asked questions
Can I take Indacaterol inhaled with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Indacaterol inhaled and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vilanterol and indacaterol are both long-acting beta2-agonists, so using them together duplicates therapy and increases adrenergic effects. Tachycardia, palpitations, tremor, hypokalemia and arrhythmias become more likely, particularly in patients with cardiovascular disease.
How serious is the interaction between Indacaterol inhaled and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two LABA-containing products and choose one regimen. If an overlap has occurred, monitor heart rate, blood pressure, potassium and ECG as indicated.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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