Drug interactions
Indacaterol inhaled + Verapamil
Severity: Minor
Indacaterol inhaled and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil, a P-gp and CYP3A4 inhibitor, can increase systemic indacaterol exposure. At the recommended inhaled dose this has not been clinically significant, but higher exposure could cause tachycardia, tremor and hypokalemia.
What this interaction means in plain words
Indacaterol inhaled and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of P-glycoprotein and CYP3A4 by verapamil reduces indacaterol clearance.
What to do
No dose adjustment is needed at the recommended dose. Monitor for beta-agonist effects such as palpitations or tremor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Indacaterol inhaled with Verapamil?
MediHelp rates the interaction as minor. Indacaterol inhaled and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil, a P-gp and CYP3A4 inhibitor, can increase systemic indacaterol exposure. At the recommended inhaled dose this has not been clinically significant, but higher exposure could cause tachycardia, tremor and hypokalemia.
How serious is the interaction between Indacaterol inhaled and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed at the recommended dose. Monitor for beta-agonist effects such as palpitations or tremor.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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