Drug interactions
Indacaterol inhaled + Ziprasidone
Severity: Moderate
Indacaterol inhaled and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol, a long-acting beta-2 agonist, can cause tachycardia, hypokalemia and QT prolongation, which may add to the QT effect of ziprasidone. The risk of ventricular arrhythmia is greater in patients with other risk factors.
What this interaction means in plain words
Indacaterol inhaled and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia further increasing arrhythmia risk.
What to do
Monitor ECG and serum potassium in patients with cardiac risk factors, and correct electrolyte abnormalities. Consider alternatives to ziprasidone in patients with known QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Indacaterol inhaled with Ziprasidone?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol, a long-acting beta-2 agonist, can cause tachycardia, hypokalemia and QT prolongation, which may add to the QT effect of ziprasidone. The risk of ventricular arrhythmia is greater in patients with other risk factors.
How serious is the interaction between Indacaterol inhaled and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium in patients with cardiac risk factors, and correct electrolyte abnormalities. Consider alternatives to ziprasidone in patients with known QT prolongation.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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