Drug interactions
Indapamide + Indomethacin
Severity: Moderate
Indapamide and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can weaken the antihypertensive and diuretic effect of indapamide. The combination also increases the risk of renal impairment, particularly with dehydration or in older adults.
What this interaction means in plain words
Indapamide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins leads to sodium and water retention and reduced renal perfusion.
What to do
Monitor blood pressure, renal function, and electrolytes. Maintain hydration and limit the NSAID duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Indomethacin?
MediHelp rates the interaction as moderate. Indapamide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin can weaken the antihypertensive and diuretic effect of indapamide. The combination also increases the risk of renal impairment, particularly with dehydration or in older adults.
How serious is the interaction between Indapamide and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function, and electrolytes. Maintain hydration and limit the NSAID duration.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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