Drug interactions
Indapamide + Ipratropium-salbutamol
Severity: Moderate
Indapamide and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide is a thiazide-like diuretic that causes renal potassium loss, and salbutamol moves potassium into cells. Together they can cause significant hypokalemia, especially with high-dose or nebulized salbutamol. This can increase arrhythmia risk, and indapamide itself may prolong the QT interval.
What this interaction means in plain words
Indapamide and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive hypokalemia via renal potassium wasting and beta-2 mediated intracellular potassium shift.
What to do
Monitor serum potassium and magnesium, particularly with frequent salbutamol use, and replace deficits as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indapamide and Ipratropium-salbutamol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ipratropium-salbutamol
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Indapamide and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide is a thiazide-like diuretic that causes renal potassium loss, and salbutamol moves potassium into cells. Together they can cause significant hypokalemia, especially with high-dose or nebulized salbutamol. This can increase arrhythmia risk, and indapamide itself may prolong the QT interval.
How serious is the interaction between Indapamide and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, particularly with frequent salbutamol use, and replace deficits as needed.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
