Drug interactions
Indapamide + Irbesartan
Severity: Minor
Indapamide and Irbesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide tends to lower serum potassium while irbesartan tends to raise it, so the net effect on potassium is unpredictable. The combination is widely used for hypertension, and the ARB may partly offset diuretic-induced hypokalemia, but additive blood pressure lowering and volume depletion can occur, especially at initiation.
What this interaction means in plain words
Indapamide and Irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indapamide belongs to Cardiovascular; Irbesartan belongs to Cardiovascular.
Why it happens
Opposing effects on potassium (thiazide-like kaliuresis versus ARB-mediated aldosterone blockade) plus additive hypotensive and volume-depleting effects.
What to do
Check serum potassium, creatinine and blood pressure after starting or changing doses. No routine dose change is needed if values remain stable.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indapamide
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Indapamide with Irbesartan?
MediHelp rates the interaction as minor. Indapamide and Irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indapamide tends to lower serum potassium while irbesartan tends to raise it, so the net effect on potassium is unpredictable. The combination is widely used for hypertension, and the ARB may partly offset diuretic-induced hypokalemia, but additive blood pressure lowering and volume depletion can occur, especially at initiation.
How serious is the interaction between Indapamide and Irbesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium, creatinine and blood pressure after starting or changing doses. No routine dose change is needed if values remain stable.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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