Drug interactions
Indapamide + Lapatinib
Severity: Major
Indapamide and Lapatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib can prolong the QT interval and indapamide can add risk via hypokalemia, hypomagnesemia and its own QT effect. Lapatinib-related diarrhea may further worsen electrolyte loss.
What this interaction means in plain words
Indapamide and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indapamide belongs to Cardiovascular; Lapatinib belongs to Oncology.
Why it happens
Additive QT prolongation, with diuretic-induced electrolyte depletion increasing susceptibility.
What to do
Correct potassium and magnesium before starting lapatinib and monitor electrolytes and ECG during therapy. Consider an alternative antihypertensive if QTc lengthens.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indapamide
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Indapamide with Lapatinib?
MediHelp rates the interaction as major. Indapamide and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lapatinib can prolong the QT interval and indapamide can add risk via hypokalemia, hypomagnesemia and its own QT effect. Lapatinib-related diarrhea may further worsen electrolyte loss.
How serious is the interaction between Indapamide and Lapatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before starting lapatinib and monitor electrolytes and ECG during therapy. Consider an alternative antihypertensive if QTc lengthens.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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