Drug interactions
Indapamide + Levodopa
Severity: Moderate
Indapamide and Levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa may cause orthostatic hypotension, and combined with indapamide the blood pressure-lowering effect can be enhanced, raising the risk of dizziness and falls.
What this interaction means in plain words
Indapamide and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Levodopa belongs to Central Nervous System.
Why it happens
Additive hypotensive effects of dopaminergic vasodilation and diuretic-induced volume depletion.
What to do
Monitor sitting and standing blood pressure when starting levodopa or changing doses, and reduce the indapamide dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Indapamide with Levodopa?
MediHelp rates the interaction as moderate. Indapamide and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa may cause orthostatic hypotension, and combined with indapamide the blood pressure-lowering effect can be enhanced, raising the risk of dizziness and falls.
How serious is the interaction between Indapamide and Levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sitting and standing blood pressure when starting levodopa or changing doses, and reduce the indapamide dose if symptomatic hypotension occurs.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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