Drug interactions
Indapamide + Magnesium
Severity: Moderate
Indapamide and Magnesium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide, a thiazide-like diuretic, can increase urinary magnesium loss and cause hypomagnesemia. This may add to potassium depletion and arrhythmia risk.
What this interaction means in plain words
Indapamide and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Magnesium belongs to Gastrointestinal Tract.
Why it happens
Reduced distal tubular magnesium reabsorption increases renal excretion.
What to do
Monitor serum magnesium and potassium during long-term use and supplement if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium
- Ciprofloxacin + Magnesium Major
- Magnesium + Pancuronium Major
- Magnesium + Rocuronium Major
- Magnesium + Vecuronium Major
- Amikacin + Magnesium Moderate
- Amphotericin b deoxycholate + Magnesium Moderate
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Magnesium?
MediHelp rates the interaction as moderate. Indapamide and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide, a thiazide-like diuretic, can increase urinary magnesium loss and cause hypomagnesemia. This may add to potassium depletion and arrhythmia risk.
How serious is the interaction between Indapamide and Magnesium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and potassium during long-term use and supplement if low.
What other medicines interact with Magnesium?
MediHelp also lists interactions of Magnesium with, for example, Ciprofloxacin, Pancuronium, Rocuronium. The full list is on the Magnesium page.
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