Drug interactions
Indapamide + Methoxsalen
Severity: Moderate
Indapamide and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide, a sulfonamide-derived diuretic, can cause photosensitivity, and methoxsalen is a potent photosensitizer used with UVA exposure. Together they may increase the risk of severe phototoxic reactions such as burns and blistering.
What this interaction means in plain words
Indapamide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Methoxsalen belongs to Anti Fungals.
Why it happens
Additive photosensitizing effects of two agents that sensitize skin to ultraviolet light.
What to do
Counsel strict sun protection and review the need for indapamide during PUVA therapy. Reduce UVA dosing or consider an alternative antihypertensive if phototoxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Indapamide with Methoxsalen?
MediHelp rates the interaction as moderate. Indapamide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide, a sulfonamide-derived diuretic, can cause photosensitivity, and methoxsalen is a potent photosensitizer used with UVA exposure. Together they may increase the risk of severe phototoxic reactions such as burns and blistering.
How serious is the interaction between Indapamide and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel strict sun protection and review the need for indapamide during PUVA therapy. Reduce UVA dosing or consider an alternative antihypertensive if phototoxicity occurs.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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