Drug interactions
Indapamide + Oxaprozin
Severity: Moderate
Indapamide and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive and diuretic effects of indapamide. The combination also raises the risk of renal impairment, especially with dehydration or in older adults.
What this interaction means in plain words
Indapamide and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Oxaprozin belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit renal prostaglandin synthesis, leading to sodium and water retention and reduced renal perfusion.
What to do
Monitor blood pressure, electrolytes and renal function, and adjust antihypertensive therapy as needed. Keep NSAID use short and maintain hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Oxaprozin?
MediHelp rates the interaction as moderate. Indapamide and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive and diuretic effects of indapamide. The combination also raises the risk of renal impairment, especially with dehydration or in older adults.
How serious is the interaction between Indapamide and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, electrolytes and renal function, and adjust antihypertensive therapy as needed. Keep NSAID use short and maintain hydration.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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