Drug interactions
Indapamide + Prednisone
Severity: Moderate
Indapamide and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs promote renal potassium loss, so using them together raises the chance of hypokalemia. Low potassium can lead to weakness and cardiac arrhythmias, especially in patients taking digoxin or with heart disease.
What this interaction means in plain words
Indapamide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Prednisone belongs to Endocrine.
Why it happens
Additive kaliuresis from thiazide-like diuretic action and mineralocorticoid effect of prednisone.
What to do
Check serum potassium periodically and replace potassium when needed. Consider a potassium-sparing agent if hypokalemia persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Prednisone?
MediHelp rates the interaction as moderate. Indapamide and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs promote renal potassium loss, so using them together raises the chance of hypokalemia. Low potassium can lead to weakness and cardiac arrhythmias, especially in patients taking digoxin or with heart disease.
How serious is the interaction between Indapamide and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium periodically and replace potassium when needed. Consider a potassium-sparing agent if hypokalemia persists.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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