Drug interactions
Indapamide + Probenecid
Severity: Moderate
Indapamide and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide may raise uric acid levels and reduce the uricosuric effect of probenecid. Gout control could worsen.
What this interaction means in plain words
Indapamide and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Thiazide-like diuretics compete for renal anion secretion and promote urate retention through volume contraction.
What to do
Monitor serum uric acid and gout flares. Increase the probenecid dose or consider an alternative antihypertensive if urate control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Probenecid?
MediHelp rates the interaction as moderate. Indapamide and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide may raise uric acid levels and reduce the uricosuric effect of probenecid. Gout control could worsen.
How serious is the interaction between Indapamide and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout flares. Increase the probenecid dose or consider an alternative antihypertensive if urate control is lost.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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