Drug interactions
Indapamide + Repaglinide
Severity: Minor
Indapamide and Repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide can raise blood glucose slightly and so reduce the glucose-lowering effect of repaglinide. This is usually of limited significance at antihypertensive doses.
What this interaction means in plain words
Indapamide and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indapamide belongs to Cardiovascular; Repaglinide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: thiazide-type diuretics can impair insulin secretion and glucose tolerance.
What to do
Monitor blood glucose after starting or changing indapamide and adjust repaglinide if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indapamide
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Indapamide with Repaglinide?
MediHelp rates the interaction as minor. Indapamide and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indapamide can raise blood glucose slightly and so reduce the glucose-lowering effect of repaglinide. This is usually of limited significance at antihypertensive doses.
How serious is the interaction between Indapamide and Repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing indapamide and adjust repaglinide if control worsens.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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