Drug interactions
Indapamide + Sitagliptin
Severity: Minor
Indapamide and Sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide may slightly raise blood glucose and reduce the glycaemic benefit of sitagliptin. The effect is usually small.
What this interaction means in plain words
Indapamide and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indapamide belongs to Cardiovascular; Sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: thiazide-type diuretics can impair insulin secretion and sensitivity.
What to do
Monitor glucose or HbA1c after starting indapamide and adjust the diabetes regimen if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indapamide
Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Frequently asked questions
Can I take Indapamide with Sitagliptin?
MediHelp rates the interaction as minor. Indapamide and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indapamide may slightly raise blood glucose and reduce the glycaemic benefit of sitagliptin. The effect is usually small.
How serious is the interaction between Indapamide and Sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose or HbA1c after starting indapamide and adjust the diabetes regimen if control worsens.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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