Drug interactions
Indapamide + Treprostinil
Severity: Moderate
Indapamide and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a potent vasodilator and can lower blood pressure. Combined with indapamide, additive hypotension may occur, especially after dose changes or when volume depleted.
What this interaction means in plain words
Indapamide and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive blood pressure-lowering effects from prostacyclin-mediated vasodilation and diuretic-induced volume reduction.
What to do
Monitor blood pressure and symptoms of hypotension when initiating or titrating either drug, and reduce the diuretic dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Treprostinil
Frequently asked questions
Can I take Indapamide with Treprostinil?
MediHelp rates the interaction as moderate. Indapamide and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a potent vasodilator and can lower blood pressure. Combined with indapamide, additive hypotension may occur, especially after dose changes or when volume depleted.
How serious is the interaction between Indapamide and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when initiating or titrating either drug, and reduce the diuretic dose if needed.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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