Drug interactions
Indapamide + Voclosporin
Severity: Moderate
Indapamide and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin can prolong the QT interval at higher exposures, and indapamide can cause electrolyte disturbances that raise arrhythmia risk. Voclosporin may also cause hyperkalemia and nephrotoxicity, complicating electrolyte control with a diuretic.
What this interaction means in plain words
Indapamide and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Additive QT risk with diuretic electrolyte changes, plus calcineurin inhibitor effects on potassium and renal function.
What to do
Monitor ECG, potassium, magnesium and renal function, and correct abnormalities. Adjust diuretic dosing if volume depletion or renal decline occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indapamide and Voclosporin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Indapamide
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Indapamide with Voclosporin?
MediHelp rates the interaction as moderate. Indapamide and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin can prolong the QT interval at higher exposures, and indapamide can cause electrolyte disturbances that raise arrhythmia risk. Voclosporin may also cause hyperkalemia and nephrotoxicity, complicating electrolyte control with a diuretic.
How serious is the interaction between Indapamide and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium, magnesium and renal function, and correct abnormalities. Adjust diuretic dosing if volume depletion or renal decline occurs.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
