Drug interactions
Indinavir + Linagliptin-metformin
Severity: Moderate
Indinavir and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and P-glycoprotein and may raise linagliptin levels, though linagliptin is largely tolerated at higher exposure. Protease inhibitors can also cause insulin resistance and hyperglycemia, which may reduce the effect of both antidiabetic agents.
What this interaction means in plain words
Indinavir and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 and P-gp inhibition raises linagliptin exposure, while protease inhibitor-related insulin resistance opposes glucose lowering.
What to do
Monitor blood glucose and HbA1c regularly and adjust the antidiabetic regimen as needed; no empiric linagliptin dose change is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Frequently asked questions
Can I take Indinavir with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Indinavir and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and P-glycoprotein and may raise linagliptin levels, though linagliptin is largely tolerated at higher exposure. Protease inhibitors can also cause insulin resistance and hyperglycemia, which may reduce the effect of both antidiabetic agents.
How serious is the interaction between Indinavir and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c regularly and adjust the antidiabetic regimen as needed; no empiric linagliptin dose change is required.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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