Drug interactions
Indinavir + Nicardipine
Severity: Moderate
Indinavir and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a strong CYP3A4 inhibitor and can substantially raise nicardipine levels, leading to excessive hypotension, edema, flushing and tachycardia. Nicardipine may also modestly affect indinavir exposure, but this is of lesser concern.
What this interaction means in plain words
Indinavir and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits CYP3A4-mediated nicardipine metabolism, and nicardipine may weakly inhibit P-glycoprotein and CYP3A4 affecting indinavir.
What to do
Start with a low nicardipine dose and titrate according to blood pressure and heart rate. Be ready to reduce the dose, and monitor the antiretroviral response if nicardipine is added.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Indinavir with Nicardipine?
MediHelp rates the interaction as moderate. Indinavir and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir is a strong CYP3A4 inhibitor and can substantially raise nicardipine levels, leading to excessive hypotension, edema, flushing and tachycardia. Nicardipine may also modestly affect indinavir exposure, but this is of lesser concern.
How serious is the interaction between Indinavir and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low nicardipine dose and titrate according to blood pressure and heart rate. Be ready to reduce the dose, and monitor the antiretroviral response if nicardipine is added.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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