Drug interactions
Indinavir + Nizatidine
Severity: Moderate
Indinavir and Nizatidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir absorption depends on gastric acidity, and raising gastric pH can lower its concentrations. Reduced exposure may compromise antiviral efficacy.
What this interaction means in plain words
Indinavir and Nizatidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nizatidine raises gastric pH, decreasing the pH-dependent absorption of indinavir.
What to do
Avoid the combination if possible, or use ritonavir-boosted indinavir and monitor viral load.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Frequently asked questions
Can I take Indinavir with Nizatidine?
MediHelp rates the interaction as moderate. Indinavir and Nizatidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir absorption depends on gastric acidity, and raising gastric pH can lower its concentrations. Reduced exposure may compromise antiviral efficacy.
How serious is the interaction between Indinavir and Nizatidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or use ritonavir-boosted indinavir and monitor viral load.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.
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