Drug interactions
Indinavir + Paclitaxel
Severity: Moderate
Indinavir and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and P-glycoprotein and may increase paclitaxel exposure. Higher levels could worsen myelosuppression and neuropathy.
What this interaction means in plain words
Indinavir and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by indinavir reduces paclitaxel elimination.
What to do
Monitor blood counts and neuropathy closely, and reduce the paclitaxel dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Frequently asked questions
Can I take Indinavir with Paclitaxel?
MediHelp rates the interaction as moderate. Indinavir and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and P-glycoprotein and may increase paclitaxel exposure. Higher levels could worsen myelosuppression and neuropathy.
How serious is the interaction between Indinavir and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy closely, and reduce the paclitaxel dose if toxicity occurs.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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