Drug interactions
Indinavir + Prednisone
Severity: Moderate
Indinavir and Prednisone: moderate interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may raise prednisolone exposure modestly, increasing corticosteroid adverse effects with prolonged use. Effect is smaller than for more CYP3A4-dependent steroids.
What this interaction means in plain words
Indinavir and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 and P-glycoprotein inhibition by indinavir reduces prednisolone clearance.
What to do
Use the lowest effective prednisone dose and monitor for Cushingoid features, hyperglycemia and adrenal suppression during prolonged use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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References
- Prednisone - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Indinavir with Prednisone?
MediHelp rates the interaction as moderate. Indinavir and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and may raise prednisolone exposure modestly, increasing corticosteroid adverse effects with prolonged use. Effect is smaller than for more CYP3A4-dependent steroids.
How serious is the interaction between Indinavir and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective prednisone dose and monitor for Cushingoid features, hyperglycemia and adrenal suppression during prolonged use.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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