Drug interactions
Indinavir + Quetiapine
Severity: Major
Indinavir and Quetiapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4, the main metabolic pathway of quetiapine, and can increase quetiapine exposure. This raises the risk of marked sedation, hypotension and QT prolongation.
What this interaction means in plain words
Indinavir and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4-mediated quetiapine metabolism.
What to do
Reduce the quetiapine dose substantially (labeling suggests about one sixth of the usual dose with strong CYP3A4 inhibitors) and monitor sedation, blood pressure and QTc. Restore the dose after indinavir is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Indinavir with Quetiapine?
MediHelp rates the interaction as major. Indinavir and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indinavir inhibits CYP3A4, the main metabolic pathway of quetiapine, and can increase quetiapine exposure. This raises the risk of marked sedation, hypotension and QT prolongation.
How serious is the interaction between Indinavir and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the quetiapine dose substantially (labeling suggests about one sixth of the usual dose with strong CYP3A4 inhibitors) and monitor sedation, blood pressure and QTc. Restore the dose after indinavir is stopped.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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