Drug interactions
Indinavir + Roflumilast
Severity: Moderate
Indinavir and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a potent CYP3A4 inhibitor and may increase systemic exposure to roflumilast and its active metabolite. This may increase PDE4-related adverse effects including diarrhea, weight loss, insomnia and psychiatric symptoms.
What this interaction means in plain words
Indinavir and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits CYP3A4-mediated metabolism of roflumilast.
What to do
Monitor for gastrointestinal, weight, sleep and mood adverse effects. Consider stopping roflumilast if they emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Frequently asked questions
Can I take Indinavir with Roflumilast?
MediHelp rates the interaction as moderate. Indinavir and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir is a potent CYP3A4 inhibitor and may increase systemic exposure to roflumilast and its active metabolite. This may increase PDE4-related adverse effects including diarrhea, weight loss, insomnia and psychiatric symptoms.
How serious is the interaction between Indinavir and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal, weight, sleep and mood adverse effects. Consider stopping roflumilast if they emerge.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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