Drug interactions
Indinavir + Sertraline
Severity: Moderate
Indinavir and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4, one of the pathways metabolizing sertraline, and may raise sertraline concentrations. This could increase dose-related adverse effects, though sertraline has several alternative pathways.
What this interaction means in plain words
Indinavir and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated sertraline metabolism by indinavir.
What to do
Use the lowest effective sertraline dose and titrate to response. Monitor for serotonergic adverse effects such as nausea, tremor and agitation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Indinavir with Sertraline?
MediHelp rates the interaction as moderate. Indinavir and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4, one of the pathways metabolizing sertraline, and may raise sertraline concentrations. This could increase dose-related adverse effects, though sertraline has several alternative pathways.
How serious is the interaction between Indinavir and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective sertraline dose and titrate to response. Monitor for serotonergic adverse effects such as nausea, tremor and agitation.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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