Drug interactions
Indinavir + Terbinafine
Severity: Minor
Indinavir and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may slightly increase terbinafine levels. Because terbinafine has multiple clearance routes, the effect is likely small.
What this interaction means in plain words
Indinavir and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Indinavir inhibits CYP3A4, a minor pathway of terbinafine metabolism.
What to do
No dose change is generally needed. Monitor for terbinafine adverse effects over longer courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Indinavir with Terbinafine?
MediHelp rates the interaction as minor. Indinavir and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indinavir inhibits CYP3A4 and may slightly increase terbinafine levels. Because terbinafine has multiple clearance routes, the effect is likely small.
How serious is the interaction between Indinavir and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor for terbinafine adverse effects over longer courses.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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