Drug interactions
Indinavir + Umeclidinium-vilanterol
Severity: Moderate
Indinavir and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a strong CYP3A4 inhibitor and may increase systemic vilanterol levels. The result may be more pronounced beta-agonist effects on heart rate, QT interval and potassium.
What this interaction means in plain words
Indinavir and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits CYP3A4, reducing vilanterol clearance.
What to do
Monitor heart rate and potassium and watch for palpitations; keep to the recommended dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Frequently asked questions
Can I take Indinavir with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Indinavir and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir is a strong CYP3A4 inhibitor and may increase systemic vilanterol levels. The result may be more pronounced beta-agonist effects on heart rate, QT interval and potassium.
How serious is the interaction between Indinavir and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and potassium and watch for palpitations; keep to the recommended dose.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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