Drug interactions
Indinavir + Verapamil
Severity: Moderate
Indinavir and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir, a CYP3A4 inhibitor, can increase verapamil concentrations, risking hypotension, bradycardia and AV block. Verapamil may also modestly increase indinavir exposure.
What this interaction means in plain words
Indinavir and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mutual CYP3A4 inhibition, with verapamil also inhibiting P-glycoprotein.
What to do
Monitor heart rate, blood pressure and ECG, and reduce the verapamil dose if bradycardia or conduction delay develops. Monitor for indinavir adverse effects such as nephrolithiasis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Indinavir with Verapamil?
MediHelp rates the interaction as moderate. Indinavir and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir, a CYP3A4 inhibitor, can increase verapamil concentrations, risking hypotension, bradycardia and AV block. Verapamil may also modestly increase indinavir exposure.
How serious is the interaction between Indinavir and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, and reduce the verapamil dose if bradycardia or conduction delay develops. Monitor for indinavir adverse effects such as nephrolithiasis.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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