Drug interactions
Indinavir + Vinblastine
Severity: Major
Indinavir and Vinblastine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may substantially increase vinblastine exposure. This raises the risk of severe neutropenia, neurotoxicity and paralytic ileus.
What this interaction means in plain words
Indinavir and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Indinavir inhibits CYP3A4, decreasing vinblastine clearance.
What to do
Avoid the combination where possible by choosing an antiretroviral without CYP3A4 inhibition. If it must be used, monitor blood counts and neurologic and bowel function closely and reduce the vinblastine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vinblastine
Frequently asked questions
Can I take Indinavir with Vinblastine?
MediHelp rates the interaction as major. Indinavir and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indinavir inhibits CYP3A4 and may substantially increase vinblastine exposure. This raises the risk of severe neutropenia, neurotoxicity and paralytic ileus.
How serious is the interaction between Indinavir and Vinblastine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible by choosing an antiretroviral without CYP3A4 inhibition. If it must be used, monitor blood counts and neurologic and bowel function closely and reduce the vinblastine dose.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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