Drug interactions
Indinavir + Zafirlukast
Severity: Minor
Indinavir and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a CYP3A4 substrate and zafirlukast may raise its levels slightly. Higher indinavir exposure may increase the risk of nephrolithiasis and hyperbilirubinemia.
What this interaction means in plain words
Indinavir and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by zafirlukast reduces indinavir clearance.
What to do
No dose change is routinely needed; maintain good hydration and monitor renal function and bilirubin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Frequently asked questions
Can I take Indinavir with Zafirlukast?
MediHelp rates the interaction as minor. Indinavir and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indinavir is a CYP3A4 substrate and zafirlukast may raise its levels slightly. Higher indinavir exposure may increase the risk of nephrolithiasis and hyperbilirubinemia.
How serious is the interaction between Indinavir and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; maintain good hydration and monitor renal function and bilirubin.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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