Drug interactions
Indomethacin + Metaproterenol
Severity: Minor
Indomethacin and Metaproterenol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaproterenol can lower serum potassium through intracellular shift, while indomethacin may promote potassium retention. The net effect is unpredictable and is usually of little clinical importance.
What this interaction means in plain words
Indomethacin and Metaproterenol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing effects on potassium: beta-2 agonist cellular uptake versus NSAID reduction of renal potassium excretion.
What to do
No routine action is needed; check potassium in patients with renal impairment or on other potassium-altering drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Metaproterenol?
MediHelp rates the interaction as minor. Indomethacin and Metaproterenol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metaproterenol can lower serum potassium through intracellular shift, while indomethacin may promote potassium retention. The net effect is unpredictable and is usually of little clinical importance.
How serious is the interaction between Indomethacin and Metaproterenol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; check potassium in patients with renal impairment or on other potassium-altering drugs.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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