Drug interactions
Indomethacin + Methyclothiazide
Severity: Moderate
Indomethacin and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can reduce the diuretic and antihypertensive effect of thiazides through sodium and water retention, and it may add to the risk of renal impairment in volume-depleted patients. Potassium effects oppose each other and are usually minor.
What this interaction means in plain words
Indomethacin and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces natriuresis and renal blood flow, antagonizing thiazide effects.
What to do
Monitor blood pressure, fluid status, and renal function when indomethacin is used with thiazide diuretics. Adjust the antihypertensive regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Methyclothiazide?
MediHelp rates the interaction as moderate. Indomethacin and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin can reduce the diuretic and antihypertensive effect of thiazides through sodium and water retention, and it may add to the risk of renal impairment in volume-depleted patients. Potassium effects oppose each other and are usually minor.
How serious is the interaction between Indomethacin and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, and renal function when indomethacin is used with thiazide diuretics. Adjust the antihypertensive regimen if control worsens.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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