Drug interactions
Indomethacin + Mycophenolate
Severity: Moderate
Indomethacin and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin may compete with mycophenolic acid glucuronide for renal tubular secretion, potentially raising exposure to mycophenolate metabolites. Both drugs can cause gastrointestinal toxicity and NSAIDs may harm renal function in transplant patients.
What this interaction means in plain words
Indomethacin and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion by organic anion transporters, plus additive GI and renal toxicity.
What to do
Monitor renal function, blood counts and GI symptoms, and avoid NSAIDs in transplant recipients when possible. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Mycophenolate?
MediHelp rates the interaction as moderate. Indomethacin and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin may compete with mycophenolic acid glucuronide for renal tubular secretion, potentially raising exposure to mycophenolate metabolites. Both drugs can cause gastrointestinal toxicity and NSAIDs may harm renal function in transplant patients.
How serious is the interaction between Indomethacin and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, blood counts and GI symptoms, and avoid NSAIDs in transplant recipients when possible. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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