Drug interactions
Indomethacin + Nefazodone
Severity: Moderate
Indomethacin and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonergic antidepressants impair platelet serotonin uptake and can increase bleeding risk, particularly upper GI bleeding when combined with NSAIDs. Nefazodone has weaker serotonin reuptake effects than SSRIs, so the risk is probably lower but still plausible.
What this interaction means in plain words
Indomethacin and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet function from serotonin reuptake inhibition and NSAID cyclooxygenase inhibition, with NSAID gastric mucosal injury.
What to do
Monitor for GI bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Prefer an alternative analgesic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Nefazodone?
MediHelp rates the interaction as moderate. Indomethacin and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Serotonergic antidepressants impair platelet serotonin uptake and can increase bleeding risk, particularly upper GI bleeding when combined with NSAIDs. Nefazodone has weaker serotonin reuptake effects than SSRIs, so the risk is probably lower but still plausible.
How serious is the interaction between Indomethacin and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and consider gastroprotection with a proton pump inhibitor in high-risk patients. Prefer an alternative analgesic where possible.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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