Drug interactions
Indomethacin + Neomycin po
Severity: Minor
Indomethacin and Neomycin po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
In preterm infants indomethacin reduces renal blood flow and can raise levels of renally cleared aminoglycosides. Oral neomycin is poorly absorbed, so the effect is generally limited unless absorption is increased by gut injury or the neonate is immature.
What this interaction means in plain words
Indomethacin and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Indomethacin-induced reduction in renal perfusion and glomerular filtration decreases aminoglycoside clearance.
What to do
In neonates with substantial neomycin absorption or renal impairment, monitor renal function and consider aminoglycoside levels. No action is generally needed in other patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Neomycin po?
MediHelp rates the interaction as minor. Indomethacin and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. In preterm infants indomethacin reduces renal blood flow and can raise levels of renally cleared aminoglycosides. Oral neomycin is poorly absorbed, so the effect is generally limited unless absorption is increased by gut injury or the neonate is immature.
How serious is the interaction between Indomethacin and Neomycin po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In neonates with substantial neomycin absorption or renal impairment, monitor renal function and consider aminoglycoside levels. No action is generally needed in other patients.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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