Drug interactions
Indomethacin + Noni juice
Severity: Moderate
Indomethacin and Noni juice: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Noni juice is high in potassium and indomethacin can cause potassium retention by suppressing renin and aldosterone. Together they may raise serum potassium, mainly in patients with renal impairment or on other potassium-raising drugs.
What this interaction means in plain words
Indomethacin and Noni juice can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hyperkalemia from high dietary potassium load and NSAID-induced reduction in renal potassium excretion.
What to do
Monitor serum potassium in patients with kidney disease, diabetes or on ACE inhibitors, ARBs or potassium-sparing diuretics. Limit noni juice intake in these patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Noni juice?
MediHelp rates the interaction as moderate. Indomethacin and Noni juice can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Noni juice is high in potassium and indomethacin can cause potassium retention by suppressing renin and aldosterone. Together they may raise serum potassium, mainly in patients with renal impairment or on other potassium-raising drugs.
How serious is the interaction between Indomethacin and Noni juice?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients with kidney disease, diabetes or on ACE inhibitors, ARBs or potassium-sparing diuretics. Limit noni juice intake in these patients.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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