Drug interactions
Indomethacin + Penbutolol
Severity: Moderate
Indomethacin and Penbutolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin can blunt the blood pressure lowering effect of beta-blockers by causing sodium and water retention and reducing vasodilatory prostaglandins. The effect is greatest with prolonged NSAID use.
What this interaction means in plain words
Indomethacin and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal and vascular prostaglandin synthesis opposes the antihypertensive action of beta-blockers.
What to do
Monitor blood pressure when indomethacin is started or stopped and adjust the antihypertensive dose as needed. Use the shortest NSAID course possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Penbutolol?
MediHelp rates the interaction as moderate. Indomethacin and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin can blunt the blood pressure lowering effect of beta-blockers by causing sodium and water retention and reducing vasodilatory prostaglandins. The effect is greatest with prolonged NSAID use.
How serious is the interaction between Indomethacin and Penbutolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when indomethacin is started or stopped and adjust the antihypertensive dose as needed. Use the shortest NSAID course possible.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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