Drug interactions
Indomethacin + Pindolol
Severity: Moderate
Indomethacin and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prolonged NSAID use such as indomethacin can blunt the blood pressure lowering effect of beta-blockers including pindolol. Indomethacin has been associated with the most consistent attenuation of antihypertensive response, which may lead to loss of blood pressure control.
What this interaction means in plain words
Indomethacin and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal and vascular prostaglandin synthesis by indomethacin causes sodium and water retention and reduces vasodilation, opposing the antihypertensive action of pindolol.
What to do
Monitor blood pressure when indomethacin is started, changed or stopped in a patient on pindolol. Use the lowest effective NSAID dose for the shortest time or consider a non-NSAID analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Pindolol?
MediHelp rates the interaction as moderate. Indomethacin and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prolonged NSAID use such as indomethacin can blunt the blood pressure lowering effect of beta-blockers including pindolol. Indomethacin has been associated with the most consistent attenuation of antihypertensive response, which may lead to loss of blood pressure control.
How serious is the interaction between Indomethacin and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when indomethacin is started, changed or stopped in a patient on pindolol. Use the lowest effective NSAID dose for the shortest time or consider a non-NSAID analgesic.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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