Drug interactions
Indomethacin + Reteplase
Severity: Major
Indomethacin and Reteplase: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reteplase dissolves clots and indomethacin impairs platelet function and can injure the gastric lining. Used together, the risk of serious bleeding is increased.
What this interaction means in plain words
Indomethacin and Reteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hemostatic impairment from fibrinolysis by reteplase and reversible platelet COX-1 inhibition by indomethacin.
What to do
Avoid starting or continuing NSAIDs around thrombolytic therapy unless essential, and monitor closely for bleeding including gastrointestinal and intracranial signs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Reteplase?
MediHelp rates the interaction as major. Indomethacin and Reteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Reteplase dissolves clots and indomethacin impairs platelet function and can injure the gastric lining. Used together, the risk of serious bleeding is increased.
How serious is the interaction between Indomethacin and Reteplase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting or continuing NSAIDs around thrombolytic therapy unless essential, and monitor closely for bleeding including gastrointestinal and intracranial signs.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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