Drug interactions
Indomethacin + Rivastigmine
Severity: Moderate
Indomethacin and Rivastigmine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholinesterase inhibitors increase gastric acid secretion and may raise the risk of ulcers and GI bleeding, which can add to the gastric toxicity of NSAIDs. Patients on both should be watched for GI bleeding.
What this interaction means in plain words
Indomethacin and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indomethacin belongs to Musculoskeletal; Rivastigmine belongs to Central Nervous System.
Why it happens
Cholinergic stimulation of gastric acid secretion adds to NSAID-induced loss of mucosal protection.
What to do
Monitor for dyspepsia, melena or anemia and consider gastroprotection with a proton pump inhibitor in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Rivastigmine
Frequently asked questions
Can I take Indomethacin with Rivastigmine?
MediHelp rates the interaction as moderate. Indomethacin and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholinesterase inhibitors increase gastric acid secretion and may raise the risk of ulcers and GI bleeding, which can add to the gastric toxicity of NSAIDs. Patients on both should be watched for GI bleeding.
How serious is the interaction between Indomethacin and Rivastigmine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dyspepsia, melena or anemia and consider gastroprotection with a proton pump inhibitor in high-risk patients.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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