Drug interactions
Indomethacin + Saw palmetto
Severity: Minor
Indomethacin and Saw palmetto: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saw palmetto has been associated with isolated reports of bleeding and may theoretically add to the bleeding risk of NSAIDs. The evidence is limited.
What this interaction means in plain words
Indomethacin and Saw palmetto have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indomethacin belongs to Musculoskeletal; Saw palmetto belongs to Gastrointestinal Tract.
Why it happens
Possible weak antiplatelet or prostaglandin-inhibiting activity of saw palmetto; the mechanism is not well established.
What to do
Ask patients about herbal use and counsel them to report bruising or bleeding. Stop saw palmetto before surgery.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Saw palmetto
- Aspirin rectal + Saw palmetto Moderate
- Aspirin + Saw palmetto Moderate
- Dabigatran + Saw palmetto Moderate
- Desirudin + Saw palmetto Moderate
- Ketorolac + Saw palmetto Moderate
- Meclofenamate + Saw palmetto Moderate
Frequently asked questions
Can I take Indomethacin with Saw palmetto?
MediHelp rates the interaction as minor. Indomethacin and Saw palmetto have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Saw palmetto has been associated with isolated reports of bleeding and may theoretically add to the bleeding risk of NSAIDs. The evidence is limited.
How serious is the interaction between Indomethacin and Saw palmetto?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about herbal use and counsel them to report bruising or bleeding. Stop saw palmetto before surgery.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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