Drug interactions
Indomethacin + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Indomethacin and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfate-based bowel preparations can cause fluid and electrolyte disturbances, and NSAIDs add renal risk. The combination may increase the chance of renal impairment, arrhythmia and seizures from electrolyte abnormalities.
What this interaction means in plain words
Indomethacin and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Volume and electrolyte shifts from the preparation combine with NSAID-induced reduction in renal blood flow and water excretion.
What to do
Maintain hydration and consider holding indomethacin during bowel preparation; check electrolytes and renal function in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Indomethacin and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfate-based bowel preparations can cause fluid and electrolyte disturbances, and NSAIDs add renal risk. The combination may increase the chance of renal impairment, arrhythmia and seizures from electrolyte abnormalities.
How serious is the interaction between Indomethacin and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and consider holding indomethacin during bowel preparation; check electrolytes and renal function in high-risk patients.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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