Drug interactions
Indomethacin + Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol
Severity: Moderate
Indomethacin and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations can cause electrolyte disturbance and fluid shifts, and NSAIDs can promote water retention and impair renal function. Together this raises the risk of hyponatremia and acute kidney injury.
What this interaction means in plain words
Indomethacin and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-related impairment of free water excretion and renal perfusion adds to fluid and electrolyte shifts from the preparation.
What to do
Advise adequate fluid intake and consider pausing indomethacin around the preparation; check sodium and renal function in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates the interaction as moderate. Indomethacin and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations can cause electrolyte disturbance and fluid shifts, and NSAIDs can promote water retention and impair renal function. Together this raises the risk of hyponatremia and acute kidney injury.
How serious is the interaction between Indomethacin and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise adequate fluid intake and consider pausing indomethacin around the preparation; check sodium and renal function in at-risk patients.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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