Drug interactions
Indomethacin + Sulfadiazine
Severity: Minor
Indomethacin and Sulfadiazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs that are highly protein-bound may displace sulfonamides and reduce their renal elimination, possibly raising sulfadiazine concentrations. Clinical significance is unproven.
What this interaction means in plain words
Indomethacin and Sulfadiazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible protein-binding displacement and competition for renal tubular secretion; mechanism not firmly established.
What to do
No routine change is needed. Monitor for sulfonamide adverse effects and renal function, especially at high doses or in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Indomethacin with Sulfadiazine?
MediHelp rates the interaction as minor. Indomethacin and Sulfadiazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs that are highly protein-bound may displace sulfonamides and reduce their renal elimination, possibly raising sulfadiazine concentrations. Clinical significance is unproven.
How serious is the interaction between Indomethacin and Sulfadiazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor for sulfonamide adverse effects and renal function, especially at high doses or in renal impairment.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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